A Review of Synthesis Methods of Chalcones, Flavonoids, and Coumarins

Chalcones are the primary building blocks for flavonoids and isoflavonoids production. a three-carbon, -unsaturated carbonyl system. form when an aromatic aldehyde reacts with acetophenones in presence of catalyst. For synthesis these molecules, variety methods approaches have been reported. The Aldol condensation Claisen-Schmidt reactions most commonly referenced synthetic protocols literature, but Suzuki reaction, Witting Photo-Fries rearrangement also employed as procedures within chalcone framework. SOCl2 natural phosphate, lithium nitrate, amino grafted zeolites, zinc oxide, water, K2CO3, PEG400, silica sulfuric acid, ZrCl4, ionic liquid among used catalysts